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| 01/08/2010 07:37:19 |
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| Thank you to 'Stitches of Love and Kindness' |
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| A massive thank you to everyone at 'Stiches of Love and Kindness' who helped to make Sophie's beautiful handmade quilt. |
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| 06/04/2010 19:17:04 |
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| Thank you to Jaxson's Blankies for Babes |
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| A special thank you to Jaxson's Blankies for Babes for the special blanket sent to Sophie |
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| 14/12/2009 21:45:16 |
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| The Holly Bush launch new website |
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| The Holly Bush country pub based in Frensham launch their own website. |
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| RECENT BLOGS |
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| 01/09/2010 21:37:57 |
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| Sophie loves her new train set! |
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| Sophie has lots of fun playing with her new switch adapted Thomas the Tank Engine train set |
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| 16/08/2010 21:51:39 |
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| Lots of Water Fun and an Energy Crash |
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| Sophie had a great July with lots of tomboy fun. Unfortunately the end of July and early August bought with it an energy crash. |
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LATEST NEWS
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| 04/08/2009 22:45:29 |
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| Comparative Analyses of Disease Risk Genes Belonging to the Acyl-CoA Synthetase Medium-Chain (ACSM) Family in Human Liver and Cell Lines |
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The human ACSM1, 2A and B, 3, and 5 genes, located on chromosome 16p12-13, encode for enzymes catalyzing the activation of medium-chain length fatty acids. Association studies have linked several polymorphisms of these genes to traits of insulin resistance syndrome. In our study, ACSM transcripts showed 3 to >400-fold higher expression levels in human liver when compared to cell lines by qRT-PCR.
This difference was also evident at the protein level, as shown for ACSM2. In liver, ACSM2 was the most abundant transcript, showing sixfold (vs. ACSM3) to >300-fold higher expression levels (vs. ACSM1). Mitochondrial localization of the ACSM2 protein and the presence of an N-terminal targeting sequence were shown by GFP-tagging. We have shown ACSM2B to be the predominant transcript in human liver, and genetic variations of this gene could therefore play an important role in disease susceptibility. |
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